Overview Video of mRNA Vaccine Expertise

This text was initially revealed right here.

This 25 minutes video explains intimately the mechanisms of motion for mRNA COVID-19 vaccines, in addition to highlighting a few of the identified dangers. If you need a greater understanding of the know-how or want for a refresher on the tech, in addition to to be taught a little bit of mobile and molecular biology – this can be a nice primer. So, sit again, chill out and open your thoughts to a little bit of science.

Evaluation of the Peer Reviewed Research

Neutralizing Antibodies In opposition to the SARS-CoV-2 Omicron Variant (BA.1) 1 to 18 Weeks After the Second and Third Doses of the BNT162b2 mRNA Vaccine. JAMA Netw Open. 2022;5(5):e2212073. doi:10.1001/jamanetworkopen.2022.12073

The summary of the paper first mentions that in early scientific trials, SARS-CoV-2 neutralizing antibodies have been correlated with safety towards an infection and illness attributable to early viral variants, however not talked about by the authors – this correlation has not been demonstrated with the assorted Omicron variants.

The authors of this present work, which focuses on the Pfizer/BioNTech vaccine, notice that in research carried out by Moderna, there’s an noticed lower in neutralizing antibody titers within the vaccinated inhabitants which corresponds to a lower in vaccine efficacy towards polymerase chain response – confirmed Omicron an infection in Denmark and symptomatic Omicron an infection in the UK.

The research has a curious choice bias – it solely contains males, and it neither captures nor analyzes any information regarding efficacy or effectiveness endpoints.

This research repeatedly asserts that there’s a demonstrated correlation between neutralizing antibody titers and safety towards an infection and illness, however depends on historic information from non-Omicron variants to help this declare.

  • This research detected a speedy decline in Omicron-specific serum neutralizing antibody titers only some weeks after the second and third doses of BNT162b2.
  • For these aged 65 and older, there have been virtually no Omicron-specific serum neutralizing antibody titers after dose 2 (see Determine 2, panel B).
  • For these aged 65 and older, there have been virtually no Omicron-specific serum neutralizing antibody titers by week 8 after dose 3.

Please evaluate Determine 2, which clearly reveals these outcomes:

temporal omicron virus neutralization titers

Taken collectively, this work clearly demonstrates that vaccine-induced protecting antibody responses following a second and third dose of BNT162b2 are each very low and transient in older individuals (which is the cohort at most important threat of hospitalization and loss of life).

The article mentions that conserved T-cell immunity and non-neutralizing antibodies should still present safety towards hospitalization and loss of life whilst neutralizing antibodies wane, however the research didn’t truly measure T-cell immunity and non-neutralizing antibodies.

The authors conclude that “further booster doses could also be obligatory, significantly in older individuals.” Following their logic, one can view the above desk and notice that the ranges of safety quickly wanes after week 4 in these older than 65 years after dose 3. One has to marvel, whether or not the research authors actually imply to suggest {that a} whole of 13 boosters per yr are wanted (52 weeks/4 weeks = 13 boosters)? Or are they only scripting this to get by way of peer evaluate?

Additionally related is that “validated correlate of safety” is a exact regulatory time period. It implies that intensive evaluation and characterization of each the particular take a look at used (neutralizing antibodies towards SARS-CoV-2), in addition to the connection between what it’s testing and the factor that it’s being developed to function a surrogate for (safety) has been carried out. Within the case of the present research, neither has occurred.

Due to this fact, no conclusions may be drawn from this research regarding what it’s measuring (presupposed to be neutralizing antibodies) and the endpoint for which it’s to function a surrogate for (safety) may be drawn. In different phrases, this paper is actually a preliminary research of no actual regulatory significance — it has not been carried out with the required rigor.

A extra unbiased conclusion based mostly on these information is that the Pfizer/BioNTech BNT162b2 vaccine has exceptionally poor sturdiness of neutralizing antibody response (utilizing a non-validated or “tutorial analysis” stage take a look at) towards at the moment circulating viral strains.

In distinction, rising mRNA vaccine effectiveness information from a number of nations are repeatedly demonstrating a dose dependent adverse effectiveness of those vaccines (in different phrases, the extra doses administered, the upper the chance of serious COVID illness or loss of life).

The failure to deal with these information clearly demonstrates, as soon as once more, each the failure of the peer evaluate course of, the irrational pro-vaccine bias of the authors, and the pro-vaccine bias of the editors of the Journal of the American Medical Affiliation.

When will goal, data-driven physicians and medical scientists ever have the ability to restore their prior religion within the Journal of the American Medical Affiliation, or will JAMA proceed to stay (for all sensible functions) only a pharmaceutical trade promotional commerce journal?

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