This text was beforehand printed February 28, 2021, and has been up to date with new info.
On this interview, Stephanie Seneff, Ph.D., a senior analysis scientist at MIT, evaluations the well being impacts of glyphosate. She has simply completed writing a e book about glyphosate known as “Poisonous Legacy: How the Weedkiller Glyphosate is Destroying Our Well being and the Setting,” which is anticipated to be printed in June 2021.
For years, glyphosate was assumed secure and claims of toxicity had been vehemently denied. However lately, research on glyphosate have been demonstrating toxicity even at very low ranges. Seneff additionally believes glyphosate publicity could also be a key participant in circumstances of extreme COVID-19, which we’ll unravel on this interview.
Glyphosate’s Mechanism of Motion
The “gly” in glyphosate really stands for the amino acid glycine. The glycine amino acid in glyphosate has a methylphosphonate group connected to its nitrogen atom, which is answerable for its results and toxicity.
After learning the analysis literature on glyphosate, Seneff has reached the conclusion that your physique typically substitutes glyphosate for the amino acid glycine when it’s setting up proteins, and this may have devastating penalties in some circumstances. The proteins created with glyphosate as an alternative of glycine merely do not work as a result of glyphosate is way bigger than glycine and in addition negatively charged, and because of this this alters vital bodily traits.
Monsanto’s personal analysis, courting again to the late Eighties, reveals that glyphosate accumulates in numerous tissues, although they declare it would not.1 The Monsanto researchers proposed that it was “integrated into” the proteins within the tissues. This isn’t broadly appreciated, even within the pure well being group.
Now, in case you have a distorted analog of glycine (within the type of glyphosate), the protein constructed from it’s not going to work prefer it’s alleged to. In her e book, Seneff particulars the amino acids in proteins which are most vulnerable to wreck due to what she calls a “glyphosate vulnerable motif.”
“It is actually fascinating biology and so terrifying if you consider the potential penalties, if I am proper,” she says. “It matches so properly with all of the illnesses which are going up dramatically in our society that I actually assume I am onto one thing large right here.”
An fragrant amino acid known as EPSP synthase is a crucial enzyme that just about absolutely will get disrupted by glyphosate by this mechanism of substituting for glycine. This will get a bit technical, however it will be significant. The plant model of EPSP synthase binds a phosphate group in its substrate phosphoenolpyruvate at a website the place there’s a highly-conserved glycine residue (extremely conserved often implies that it’s crucial for correct operate).
It has been proven experimentally that, in the event you change the DNA code in order that the glycine is substituted by an amino acid known as alanine (one additional methyl group), the enzyme turns into utterly insensitive to glyphosate at any focus. It additionally takes successful on phosphate binding due to the additional methyl group, however you possibly can tweak one other amino acid close by to repair this downside, whereas nonetheless holding its insensitivity to glyphosate.
Researchers from Dow-Dupont did precisely this to a maize model of EPSP synthase utilizing CRISPR expertise and had been in a position to create synthetically a model of the maize’s personal EPSP synthase that was utterly immune to glyphosate. The title of this paper is: “Desensitizing Plant EPSP Synthase to Glyphosate: Optimized International Sequence Context Accommodates a Glycine-to-Alanine Change within the Lively Website.”2
The shikimate pathway is the pathway that produces fragrant amino acids, that are important to people as we can not create these amino acids in our physique. The argument is we’re not vulnerable to glyphosate as a result of our cells haven’t got EPSP synthase — the truth is, they do not have the complete shikimate pathway.
Nonetheless, our intestine microbes do have that pathway, and so they use it to make important amino acids for the host. So, our intestine microbes are certainly affected by glyphosate, and once they’re broken, our well being can endure in any variety of methods.
However what is likely to be an much more devastating downside with glyphosate is the best way it most likely messes up numerous proteins that bind phosphate at a website the place there may be not less than one, and sometimes three, extremely conserved glycine residues. Glyphosate slips its methylphosphonate group into the spot that’s alleged to be the place phosphate from the substrate suits snugly. Phosphate cannot bind as a result of glyphosate is in the best way.
The arguments for why glyphosate particularly disrupts proteins that depend upon glycine for phosphate binding are described extra totally in a paper Seneff printed along with colleagues arguing that glyphosate is a significant component in kidney failure amongst younger agricultural staff in Central America.3
The Significance of Deuterium
Laszlo Boros is a professor of pediatrics at UCLA and an skilled on deutenomics, “the science of autonomic deuterium discrimination in nature.”4 After studying certainly one of Seneff’s papers, he contacted her, suggesting she look into deuterium.
“I used to be blown away, and I instantly noticed the connection to glyphosate,” she says. “This was a 12 months in the past in December, and I’ve simply been studying every part I can on deuterium since then and hooking it to glyphosate. It is simply astonishing what I discovered, even, finally, [linking it] to COVID-19.
It has been fairly a 12 months for me by way of main breakthroughs in my understanding of how metabolism works and the way it’s getting tousled by glyphosate, after which how that is inflicting us to not have the ability to successfully take care of COVID-19.”
In regular physiology, your cells, particularly the mitochondria, operate to assist deplete your physique of deuterium. Deuterium is a naturally occurring isotope of hydrogen. In the event you did not already know, deuterium is often known as heavy hydrogen, as a result of it has a neutron along with the proton and electron within the hydrogen atom.
Offered your cell is wholesome, it has deuterium-depleting enzymes and organelles that assist take away deuterium out of your cells. In case your mitochondria are broken by glyphosate, they don’t seem to be going to have the ability to remove the deuterium correctly.
Deuterium is like iron in the best way that it is each important in the correct quantities and poisonous in extra. Hydrogen is the smallest atom and by far the commonest atom in your physique. Deuterium, being a heavy hydrogen, has one additional neutron, along with the traditional proton and electron that common hydrogen has.
Now, your cells are surrounded by structured water, which is negatively charged and contributes to your physique’s vitality manufacturing by supplying deuterium-depleted hydrogen to lysosomes and mitochondria. The structured water is maintained by sulfates, which makes sulfate extraordinarily vital for well being. Sulfate is made dysfunctional by glyphosate, which in flip destroys structured water, leading to impaired vitality manufacturing within the cell.5
“The mitochondria have [a] membrane, which has a component contained in the membrane that is actually, actually vital,” Seneff says. “That is the place you could have these protons, and you actually don’t need it to be deuterons. That is what Laszlo introduced house to me.”
How Your Physique Creates Deuterium-Depleted Water
Endothelial NOS (eNOS) makes nitric oxide (NO), and for each molecule of NO that it makes, it produces two molecules of water, that are deuterium depleted. Stephanie believes the NO created by eNOS might act as a sign that deuterium-depleted water has been created. Curiously sufficient, deuterium-depleted water can be created throughout the inflammatory course of.
“The irritation is there for a very good motive, and the reason being to provide deuterium-depleted water,” Seneff says. “It is all as a result of the mitochondria are failing of their activity of manufacturing their very own deuterium-depleted water, which they get partly by the structured water from the sulfate [and] by enzymes which are extremely expert at selecting hydrogen over deuterium …
NADH and NADPH are additionally fascinating. I have been chasing them by all of the proteins. They’re fascinating as a result of they’re the carriers of that fantastic hydrogen that is not deuterium. If you hint what’s doing what, the place, you notice that the cytoplasm is producing NADH and handing it over to the mitochondria.
The mitochondria then take that H [hydrogen atom] off and throw it into the intermembrane area. So, the entire course of finally ends up with the intermembrane area being assured that that is H [hydrogen] and never D [deuterium].
That is essential as a result of then these protons, as soon as they construct up, come again by the ATPase [ATP synthase] pump. If they’re deuterons, they’re going to wreck the pump … You launch reactive oxygen species [that] break it, and naturally, then you possibly can’t make ATP.”
For clarification, the ATP synthase pump works like a mini-motor. When a hydrogen atom with one proton goes by it, it really works flawlessly and generates ATP. If deuterium enters it, which has one neutron and one proton, making it twice the load of hydrogen, it breaks that motor.
Curiously, deuterium is in all places, naturally, however your physique has developed an intricate technique to make it innocent by trapping it within the structured water, the place it is helpful, because it really helps the creation of structured water.
Issues come up if you can not make sufficient structured water to sequester all of it. Then, the deuterium will get unfastened, inflicting mitochondrial dysfunction, impairing vitality manufacturing and contributing to persistent illness.
Glyphosate Damages Well being in Many Methods
As famous by Seneff, glyphosate harms your well being in quite a few methods. For instance, she cites a latest paper displaying it causes endocrine disruption, which might result in breast most cancers, reproductive points, weight problems and thyroid issues.6
One other paper reveals glyphosate sensitizes cells to be extra receptive to most cancers after publicity to different chemical substances.7 “Glyphosate makes every part else extra poisonous than it might in any other case be,” Seneff says. “It disrupts your protection system in opposition to poisonous chemical substances.” Different analysis reveals epigenetic and generational results, even when no obvious issues will be discovered within the first technology uncovered.8
Glyphosate additionally impairs flavoproteins — proteins that bind flavins. Many of those proteins play an important position in transferring hydrogen from NADH or NADPH to different molecules, primarily supporting the supply of pure hydrogen to the mitochondria. Flavoproteins have a attribute GxGxxG motif on the website the place they bind phosphate within the flavins. The ‘G’ stands for glycine and the ‘x’ is a wildcard — any amino acid, together with glycine.
This implies they’ve not less than three vulnerable glycines at this crucial area of the protein. Flavoproteins are molecules that facilitate the switch of protons and electrons, and know how you can keep away from deuterium, by exploiting a particular characteristic of hydrogen known as proton tunneling.
All of them will be anticipated to be disrupted by glyphosate. A crucial flavoprotein is succinate dehydrogenase, and several other papers have proven it’s adversely affected by glyphosate, Seneff says. It’s the solely enzyme that performs a job in each oxidative phosphorylation and the citric acid cycle within the mitochondria.
Along with fragrant amino acids, the shikimate pathway is important for riboflavin synthesis, and riboflavin, a B vitamin, is the primary precursor to flavins. Which means riboflavin deficiency will be triggered from glyphosate publicity as properly.
Glyphosate additionally causes injury by:
- Growing calcium uptake in cells, which causes toxicity to neurons
- Interfering with the power to take glutamate out of your synapses
- Making manganese unavailable — This in flip disrupts and prevents glutamate from being become unhazardous glutamine after it is eliminated out of your synapses. The enzyme answerable for the conversion can be extremely depending on glycine, which may very well be changed by glyphosate
Deuterium-Depleted Water Could Be Central to Metabolism
Based on Seneff, it seems deuterium-depleted water performs a central, hitherto unappreciated position in metabolism, as your physique has so some ways to create it. For instance, deuterium-depleted water is created by:
• Fatty acid synthesis and metabolism — The enzymes that synthesize fatty acids incorporate hydrogen that’s carried by NADPH. This hydrogen atom has been fastidiously chosen to be assured to not be deuterium. Curiously, lipoxygenase is a protein expressed throughout circumstances of stress, and in response to Seneff, it has the best capacity to pick out protons over deuterons of any protein.
It’s extremely upregulated in extreme COVID-19 an infection. It seems the virus triggers a rise in lipoxygenase as a result of the virus captures linoleic acid (LA) in pockets within the viral membrane. Nonetheless, lipoxygenase will not be a flavoprotein, and it additionally would not bind heme — this makes it resistant to wreck from glyphosate. So, its activation turns into an alternate pathway to repair the mitochondrial deuterium downside.
SARS-CoV-2 picks up the omega-6 LA because it crosses the mobile membrane, and the LA then triggers the manufacturing of lipoxygenase that modifies the LA into leukotrienes — signaling molecules that herald damaging macrophages.
However deuterium-depleted water can be produced on this course of, by yanking two hydrogen atoms out of the fats and mixing them with oxygen to make water. Be aware that that is simply yet one more means that extra LA damages your physique, however with an ulterior motive that we frequently fail to understand.
• Sterol synthesis and metabolism — together with ldl cholesterol, vitamin D, cortisol, and intercourse hormones.
• Fragrant amino acid derivatives — together with melatonin and neurotransmitters similar to dopamine and serotonin, in addition to thyroid hormone.
“All these molecules that undergo these difficult steps are all targeted on delivering deuterium-depleted water to the mitochondria,” Seneff says. “I imply, it is an absolute obsession that the cell has.” She goes on to evaluation how processes which will seem to don’t have anything however dangerous results are literally an effort to heal the physique. This, for instance, appears to be the case in COVID-19:
“I imagine that no matter biology is doing, it is doing it for a very good motive. There could also be injury, however there is a good motive why you want that injury so as to survive long run. It is making an attempt to repair an issue that is very severe, and that is what I believe is going on with [SARS-CoV-2].
Not solely does it induce this lipoxygenase, which produces deuterium-depleted water, it then creates this inflammatory surroundings, which brings within the platelets and the macrophages, the immune cells and the stem cells. All these are having an enormous social gathering in there in all this fluid that is build up contained in the lungs.
In the meantime, it additionally will increase the manufacturing of hyaluronic acid. Hyaluronic acid is ready to lure deuterium-depleted water. It makes structured water. So, you get structured water contained in the alveoli of the lungs, and you then get fluid water within the interstitial areas.
The blood vessels are leaky, the capillaries are leaky. Every little thing’s popping out of the capillaries into this interstitial area the place there’s this fluid water, and you have this lipoxygenase making deuterium-depleted water.
So, you are producing this surroundings of deuterium-depleted water, inviting the macrophages to return in, and the platelets launch their mitochondria … the stem cells additionally are available in and launch their mitochondria, after which macrophages sweep up the mitochondria — and all that is taking place within the interstitial area within the lungs the place the fluid is. Because of this you can not breathe. You are drowning.
Possibly one of the crucial vital issues platelets do is cling on to mitochondria that they’ll ship to the macrophages below circumstances of stress. So, what occurs is all these mitochondria get launched in that interstitial area, and the macrophages induce this macropinocytosis, the place they really sweep up the water and every part that is in it and produce it contained in the macrophage, together with the mitochondria.
It is really been proven that platelets can launch mitochondria into the surroundings, and macrophages can take them up and use them as completely functioning mitochondria. It is astonishing. So, what they’re doing is restoring the mitochondrial well being to the immune cells.”
Glyphosate Harm Could Be a Consider Extreme COVID-19
As defined by Seneff, your immune cells are impaired by glyphosate, so the older you’re, the extra possible you have been uncovered to glyphosate for many years and subsequently have poorly functioning immune cells. Curiously, Seneff factors out that the comorbidities of COVID-19 — weight problems, diabetes and hypertension — are additionally illnesses whose prevalence goes up dramatically over time, precisely in keeping with glyphosate utilization on core crops.
“So, I believe it is principally about glyphosate,” she says. “In the event you’ve amassed loads of glyphosate in your tissues, you are not going to do properly with COVID-19, and that is as a result of [your body] is making an attempt to restore the mitochondria within the immune cells in order that the immune cells can really clear the virus. If they can not make ATP, they can not do their job, and the virus prospers.”
The important thing take-home message right here is that that is but one more reason to scrub up your eating regimen to be sure you’re not uncovered to glyphosate. It mainly wrecks your immune cells, and the cascading injury that takes place in extreme circumstances of COVID-19 seems to be your physique’s response to salvage or restore these poorly functioning immune cells.
The reply to this downside is, to start with, to eat licensed natural meals at any time when potential. “We cannot purchase it if we won’t discover licensed natural, and we have actually seen well being enhancements since we have began doing that,” Seneff says. “I actually swear by it, and I attempt to get all my pals to do the identical. I believe in the event you can remove glyphosate, you possibly can actually see nice enhancements in your well being it doesn’t matter what your issues are.” Different dietary suggestions embody consuming/ingesting extra:
Sulfur-containing meals similar to natural eggs and seafood
Natural grass fed milk and butter. Butter is likely one of the lowest deuterium meals obtainable
Glacier water, which is of course low in deuterium
Animal fat, that are additionally low in deuterium
Probiotics meals similar to sauerkraut and apple cider vinegar
To assist “push” glyphosate out of your physique and mitigate its toxicity, you possibly can take an affordable glycine complement. I take between 5 and 10 grams a day. It has a lightweight, candy style, so you possibly can really use it as a sweetener.
“It is sensible as a result of it is mainly going to outnumber the glyphosate molecules,” Seneff says. “Keep in mind, glyphosate’s going to compete with glycine in constructing the protein. If there’s loads of glycine round, then it is a lot much less possible that glyphosate will get in there.”