By Robert Preidt
THURSDAY, Dec. 2, 2021 (HealthDay Information) — Which coronavirus vaccine is finest at beating COVID-19 — Moderna or Pfizer?
New analysis fingers that honor to Moderna: In what’s billed as the primary head-to-head comparability of the 2 photographs, researchers analyzed the well being information of almost 440,000 U.S. veterans who acquired one of many two vaccines between early January 2021 and mid-Might 2021. All had been adopted for twenty-four weeks.
Whereas each vaccines had been extremely efficient in stopping an infection, hospitalization and demise, the Moderna vaccine conferred a 21% decrease threat of an infection and a 41% decrease threat of hospitalization.
“Each vaccines are extremely efficient, with solely uncommon breakthrough circumstances,” stated analysis crew member Dr. J.P. Casas, an epidemiologist and affiliate professor with Brigham and Girls’s Hospital and Harvard Medical Faculty. He’s additionally govt director of the U.S. Division of Veterans Affairs (VA) Million Veteran Program for genetics and well being analysis.
“However whatever the predominant pressure — Alpha earlier after which Delta later — Moderna was proven to be barely simpler,” Casas famous in a VA information launch.
The an infection fee in the course of the follow-up interval was 4.52 per 1,000 within the Moderna vaccine group and 5.75 per 1,000 within the Pfizer group. These within the Pfizer group additionally had larger charges of symptomatic COVID-19 (0.44 extra per 1,000), hospitalization (0.55 extra per 1,000), ICU admission (0.10 extra per 1,000), and demise (0.02 extra per 1,000) than these within the Moderna group.
A further part of the research overlaying the interval when Delta was the principle pressure in the US confirmed that the danger of an infection was nonetheless larger amongst these within the Pfizer group (6.54 extra per 1,000) than within the Moderna group.
The findings had been printed Dec. 1 within the New England Journal of Medication.
“Given the excessive effectiveness of each the Moderna and Pfizer vaccines, confirmed by our research, both one is really helpful to any particular person supplied a alternative between the 2,” stated research first writer Barbra Dickerman, an epidemiology teacher on the Harvard T.H. Chan Faculty of Public Well being.
“Nonetheless, whereas the estimated variations in effectiveness had been small on an absolute scale, they could be significant when contemplating the massive inhabitants scale at which these vaccines are deployed. This data could also be useful for bigger decision-making our bodies,” Dickerman stated within the launch.
Additional analysis of the 2 vaccines’ effectiveness and security is required, however given “the excessive effectiveness and security profile of each mRNA vaccines, both one is strongly really helpful,” the researchers concluded.
Earlier randomized trials discovered that the Pfizer vaccine was 95% efficient and the Moderna vaccine 94% efficient towards symptomatic COVID-19 an infection, and comparable ranges of safety had been present in real-world use.
The U.S. Facilities for Illness Management and Prevention has extra on COVID-19 vaccines.
SOURCE: U.S. Division of Veterans Affairs, information launch, Dec. 1, 2021